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Tardigrade proteins: uses in research

Also: Dsup, water bears, CAHS proteins

Tardigrades survive drying, radiation, and even space. Their special proteins are studied for protecting cells and medicines.

Key measured values

Values as stated in the cited paper's abstract.

PropertyValueSource
Reduction of X-ray DNA damage in human cells by Dsup~40%Hashimoto 2016

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Timeline

  1. 2008 Tardigrades in space
  2. 2016 Dsup radiation protection
  3. 2017 Drying-survival proteins

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biology

lab biology 2016

Dsup radiation protection

Hashimoto and colleagues found the tardigrade protein Dsup reduced radiation damage in human cells.

As reported in: Hashimoto, Horikawa, Saito et al. (2016). Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature Communications. doi:10.1038/ncomms12808

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lab biology 2017

Drying-survival proteins

Boothby and colleagues showed tardigrades use disordered proteins to survive drying out.

As reported in: Boothby, Tapia, Brozena et al. (2017). Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation. Molecular Cell. doi:10.1016/j.molcel.2017.02.018

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