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Wang and colleagues studied ruminant headgear genomes and found selection on cancer-related genes that may function in deer antler development.
As reported in: Wang, Zhang, Wang et al. (2019). Genetic basis of ruminant headgear and rapid antler regeneration. Science. doi:10.1126/science.aav6335
Qin and colleagues built a single-cell atlas of antler regrowth and identified antler blastema progenitor cells with strong self-renewal.
As reported in: Qin, Zhang, Zheng et al. (2023). A population of stem cells with strong regenerative potential discovered in deer antlers. Science. doi:10.1126/science.add0488
Wang and colleagues found antler stem cells carry classic mesenchymal stem cell markers plus some embryonic stem cell markers.
As reported in: Wang, Berg, Ba et al. (2019). Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ—deer antler. Cell Death & Disease. doi:10.1038/s41419-019-1686-y