Kyrou and colleagues showed a doublesex gene drive fully suppressed caged mosquito populations.
As reported in: Kyrou, Hammond, Galizi et al. (2018). A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nature Biotechnology. doi:10.1038/nbt.4245
Hammond and colleagues built a gene drive targeting female fertility in Anopheles gambiae.
As reported in: Hammond, Galizi, Kyrou et al. (2016). A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology. doi:10.1038/nbt.3439
Gantz and colleagues built an efficient Cas9 gene drive in Anopheles stephensi.
As reported in: Gantz, Jasinskiene, Tatarenkova et al. (2015). Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1521077112
Esvelt and colleagues discussed using CRISPR gene drives to change wild populations, and safeguards.
As reported in: Esvelt, Smidler, Catteruccia et al. (2014). Concerning RNA-guided gene drives for the alteration of wild populations. eLife. doi:10.7554/eLife.03401
Cong and colleagues showed Cas9 guided by short RNAs cuts precise sites in human and mouse cells, and several sites can be edited at once.
As reported in: Cong, Ran, Cox et al. (2013). Multiplex Genome Engineering Using CRISPR/Cas Systems. Science. doi:10.1126/science.1231143
Jinek and colleagues showed Cas9 can be programmed with RNA to cut chosen DNA, work honored with the 2020 Nobel Prize in Chemistry.
As reported in: Jinek, Chylinski, Fonfara et al. (2012). A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science. doi:10.1126/science.1225829
Reported full-length spider dragline silk gene sequences as a blueprint for a high-performance biomaterial.
As reported in: Ayoub, Garb, Tinghitella et al. (2007). Blueprint for a High-Performance Biomaterial: Full-Length Spider Dragline Silk Genes. PLoS ONE. doi:10.1371/journal.pone.0000514
Chambers and colleagues found that the selenocysteine in the active site of mouse glutathione peroxidase is encoded by TGA, normally a termination codon.
As reported in: Chambers, Frampton, Goldfarb et al. (1986). The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA.. The EMBO Journal. doi:10.1002/j.1460-2075.1986.tb04350.x